Human COL8A1 protein (Recombinant) (C-His) (STJP013277)

Name: Human COL8A1 protein (Recombinant) (C-His) (STJP013277)
SKU: STJP013277-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013277-100

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Short Description	Recombinant-Human COL8A1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.2.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.
Function	Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
Protein Name	Collagen Alpha-1(Viii Chain Endothelial Collagen Cleaved Into - Vastatin
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1650814 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-8948216
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane
Alternative Protein Names	Collagen Alpha-1(Viii Chain protein Endothelial Collagen Cleaved Into - Vastatin protein COL8A1 protein C3orf7 protein

Information sourced from Uniprot.org