Human CNP protein (Recombinant) (His-Tag) (STJP018311)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CNP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NPPC |
| Gene ID | 4880 |
| Uniprot ID | ANFC_HUMAN |
| Accession Number | NP_077720.1 |
| Immunogen | Human |
| Immunogen Region | 24-126aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | CNP-22: In the kidney, predominantly expressed in the distal tubular cells (at protein level). |
| Post Translational Modifications | CNP-22: Degraded by IDE (in vitro). |
| Function | CNP-22: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3. |
| Protein Name | C-Type Natriuretic Peptide Cleaved Into - Cnp-22 - Cnp-29 - Cnp-53 |
| Database Links | Reactome: R-HSA-5578768 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-Type Natriuretic Peptide Cleaved Into - Cnp-22 - Cnp-29 - Cnp-53 proteinNPPC proteinCNP2 protein |
Information sourced from Uniprot.org