Human CNOT8 protein (Recombinant) (His-Tag) (STJP018268)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CNOT8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNOT8 |
| Gene ID | 9337 |
| Uniprot ID | CNOT8_HUMAN |
| Accession Number | NP_004770 |
| Immunogen | Human |
| Immunogen Region | 1-292aa |
| Immunogen Sequence |
Additional Info
| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 8Caf1-Like ProteinCalifpCaf2Ccr4-Associated Factor 8Caf1b |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 8 proteinCaf1-Like Protein proteinCalifp proteinCaf2 proteinCcr4-Associated Factor 8 proteinCaf1b proteinCNOT8 proteinCALIF proteinPOP2 protein |
Information sourced from Uniprot.org