Human CNOT1 protein (Recombinant) (N-His) (STJP007354)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CNOT1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CNOT1 |
| Gene ID | 23019 |
| Uniprot ID | CNOT1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln1356-Asp1607 |
Additional Info
| Function | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 1Ccr4-Associated Factor 1Negative Regulator Of Transcription Subunit 1 HomologNot1hHnot1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmP-BodyNucleusNanos2 Promotes Its Localization To P-Body |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 1 proteinCcr4-Associated Factor 1 proteinNegative Regulator Of Transcription Subunit 1 Homolog proteinNot1h proteinHnot1 proteinCNOT1 proteinCDC39 proteinKIAA1007 proteinNOT1 proteinAD-005 protein |
Information sourced from Uniprot.org