Human CNDP2/CPGL protein (Recombinant) (His-Tag) (STJP018022)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CNDP2/CPGL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNDP2 |
| Gene ID | 55748 |
| Uniprot ID | CNDP2_HUMAN |
| Accession Number | NP_060705 |
| Immunogen | Human |
| Immunogen Region | 1-475aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAALTTL FKYIDENQDR YIKKLAKWVA IQSVSAWPEK RGEIRRMMEV AAADVKQLGG SVELVDIGKQ KLPDGSEIPL PPILLGRLGS DPQKKTVCIY GHLDVQPAAL EDGWDSEPFT LVERDGKLYG RGSTDDKGPV AGWINALEAY QKTGQEIPVN VRFCLEGMEE SGSEGLDELI FARKDTFFKD VDYVCISDNY WLGKKKPC |
Additional Info
| Tissue Specificity | Isoform 1: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes. Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level). Isoform 2: Broadly expressed in fetal tissues. Expressed in adult liver and placenta. |
| Function | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis. |
| Protein Name | Cytosolic Non-Specific DipeptidaseCndp Dipeptidase 2Glutamate Carboxypeptidase-Like Protein 1Peptidase AThreonyl Dipeptidase |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Cytosolic Non-Specific Dipeptidase proteinCndp Dipeptidase 2 proteinGlutamate Carboxypeptidase-Like Protein 1 proteinPeptidase A proteinThreonyl Dipeptidase proteinCNDP2 proteinCN2 proteinCPGL proteinHEL-S-13 proteinPEPA protein |
Information sourced from Uniprot.org