Human CNBP protein (Recombinant) (His-Tag) (STJP018085)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CNBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 0.2M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNBP |
| Gene ID | 7555 |
| Uniprot ID | CNBP_HUMAN |
| Accession Number | NP_001120668 |
| Immunogen | Human |
| Immunogen Region | 1-170aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSSNECF KCGRSGHWAR ECPTGGGRGR GMRSRGRGFQ FVSSSLPDIC YRCGESGHLA KDCDLQEDAC YNCGRGGHIA KDCKEPKRER EQCCYNCGKP GHLARDCDHA DEQKCYSCGE FGHIQKDCTK VKCYRCGETG HVAINCSKTS EVNCYRCGES GHLARECTIE ATA |
Additional Info
| Tissue Specificity | Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands. |
| Post Translational Modifications | Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding. |
| Function | Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Isoform 1: Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Isoform 2: Binds to RNA. Isoform 4: Binds to RNA. Isoform 5: Binds to RNA. Isoform 6: Binds to RNA. Isoform 8: Binds to RNA. |
| Protein Name | Cchc-Type Zinc Finger Nucleic Acid Binding ProteinCellular Nucleic Acid-Binding ProteinCnbpZinc Finger Protein 9 |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumIsoform 1: CytoplasmIsoform 2: CytoplasmIsoform 4: CytoplasmIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 8: Cytoplasm |
| Alternative Protein Names | Cchc-Type Zinc Finger Nucleic Acid Binding Protein proteinCellular Nucleic Acid-Binding Protein proteinCnbp proteinZinc Finger Protein 9 proteinCNBP proteinRNF163 proteinZNF9 protein |
Information sourced from Uniprot.org