| Tissue Specificity | Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. |
| Function | Necessary for cellular interactions with laminin and the extracellular matrix. (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm. |
| Protein Name | Anthrax Toxin Receptor 2Capillary Morphogenesis Gene 2 ProteinCmg-2 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceIsoform 2: Endoplasmic Reticulum MembraneExpressed Predominantly Within The Endoplasmic Reticulum And Not At The Plasma MembraneIsoform 3: Secreted |
| Alternative Protein Names | Anthrax Toxin Receptor 2 proteinCapillary Morphogenesis Gene 2 Protein proteinCmg-2 proteinANTXR2 proteinCMG2 protein |
Information sourced from Uniprot.org
