| Short Description : | Recombinant-Human CMBL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.5 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM EDTA |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMBL |
| Gene ID: | 134147 |
| Uniprot ID: | CMBL_HUMAN |
| Accession Number: | NP_620164.1 |
| Immunogen: | Human |
| Immunogen Region: | 1-245aa |
| Immunogen Sequence: |
| Tissue Specificity | Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). |
| Function | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. |
| Protein Name | Carboxymethylenebutenolidase Homolog |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Carboxymethylenebutenolidase Homolog proteinCMBL protein |
Information sourced from Uniprot.org
