Human CLPP protein (Recombinant) (No-Tag) (STJP017208)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CLPP-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 20% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPP |
| Gene ID | 8192 |
| Uniprot ID | CLPP_HUMAN |
| Accession Number | NP_006003.1 |
| Immunogen | Human |
| Immunogen Region | 57-277aa |
| Immunogen Sequence | MPLIPIVVEQ TGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDT MQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQL YNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPA ST |
Additional Info
| Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. |
| Function | Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. |
| Protein Name | Atp-Dependent Clp Protease Proteolytic Subunit - MitochondrialCaseinolytic Mitochondrial Matrix Peptidase Proteolytic SubunitEndopeptidase Clp |
| Database Links | Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Atp-Dependent Clp Protease Proteolytic Subunit - Mitochondrial proteinCaseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit proteinEndopeptidase Clp proteinCLPP protein |
Information sourced from Uniprot.org