SDS-PAGE gel of recombinant human CLNS1A protein stained with Coomassie blue

Human CLNS1A protein (Recombinant) (His-Tag) (STJP017907)

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STJP017907
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Short Description :Recombinant-Human CLNS1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 2mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:CLNS1A
Gene ID:1207
Uniprot ID:ICLN_HUMAN
Accession Number:NP_001284
Immunogen:Human
Immunogen Region:1-237aa
Immunogen Sequence: MGSHMSFLKS FPPPGPAEGL LRQQPDTEAV LNGKGLGTGT LYIAESRLSW LDGSGLGFSL EYPTISLHAL SRDRSDCLGE HLYVMVNAKF EEESKEPVAD EEEEDSDDDV EPITEFRFVP SDKSALEAMF TAMCECQALH PDPEDEDSDD YDGEEYDVEA HEQGQGDIPT FYTYEEGLSH LTAEGQATLE RLEGMLSQSV SSQYNM
Function Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Protein Name Methylosome Subunit Picln
Chloride Channel - Nucleotide Sensitive 1a
Chloride Conductance Regulatory Protein Icln
I(Cln
Chloride Ion Current Inducer Protein
Clci
Reticulocyte Picln
Database Links Reactome: R-HSA-191859
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Cytoskeleton
A Small Fraction Is Also Associated With The Cytoskeleton
Alternative Protein Names Methylosome Subunit Picln protein
Chloride Channel - Nucleotide Sensitive 1a protein
Chloride Conductance Regulatory Protein Icln protein
I(Cln protein
Chloride Ion Current Inducer Protein protein
Clci protein
Reticulocyte Picln protein
CLNS1A protein
CLCI protein
ICLN protein

Information sourced from Uniprot.org

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