Human CLIC4 protein (Recombinant) (N-His) (STJP006291)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLIC4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CLIC4 |
| Gene ID | 25932 |
| Uniprot ID | CLIC4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys253 |
Additional Info
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. |
| Protein Name | Chloride Intracellular Channel Protein 4Glutaredoxin-Like Oxidoreductase Clic4Intracellular Chloride Ion Channel Protein P64h1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinNucleusCell MembraneMitochondrionCell JunctionEndoplasmic Reticulum MembraneColocalized With Akap9 At The Centrosome And MidbodyExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainPresent In An Intracellular Vesicular Compartment That Likely Represent Trans-Golgi Network VesiclesMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Protein Names | Chloride Intracellular Channel Protein 4 proteinGlutaredoxin-Like Oxidoreductase Clic4 proteinIntracellular Chloride Ion Channel Protein P64h1 proteinCLIC4 protein |
Information sourced from Uniprot.org