Human CLIC3 protein (Recombinant) (C-His) (STJP014312)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLIC3-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 200mM Sucrose, 0.05% Tween 80 (w/v) , pH 8.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CLIC3 |
| Gene ID | 9022 |
| Uniprot ID | CLIC3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg236 |
Additional Info
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. |
| Protein Name | Chloride Intracellular Channel Protein 3Glutaredoxin-Like Oxidoreductase Clic3 |
| Database Links | |
| Cellular Localisation | NucleusMembraneSingle-Pass Membrane ProteinCell MembraneCytoplasmSecretedExtracellular SpaceExtracellular MatrixPredominantly NuclearSome Protein Was Found In The CytoplasmExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainSecreted Into The Extracellular Matrix By Activated Fibroblasts |
| Alternative Protein Names | Chloride Intracellular Channel Protein 3 proteinGlutaredoxin-Like Oxidoreductase Clic3 proteinCLIC3 protein |
Information sourced from Uniprot.org