Human CLIC2 protein (Recombinant) (His-Tag) (STJP017156)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CLIC2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl and 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLIC2 |
| Gene ID | 1193 |
| Uniprot ID | CLIC2_HUMAN |
| Accession Number | NP_001280 |
| Immunogen | Human |
| Immunogen Region | 1-247aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
| Protein Name | Chloride Intracellular Channel Protein 2Glutaredoxin-Like Oxidoreductase Clic2Glutaredoxin-Like Peroxidase Clic2Xap121 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | CytoplasmMembraneSingle-Pass Membrane ProteinExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain |
| Alternative Protein Names | Chloride Intracellular Channel Protein 2 proteinGlutaredoxin-Like Oxidoreductase Clic2 proteinGlutaredoxin-Like Peroxidase Clic2 proteinXap121 proteinCLIC2 protein |
Information sourced from Uniprot.org