Human CLIC1 protein (Recombinant) (N-His) (STJP014253)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLIC1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 100mM NaCl, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | CLIC1 |
| Gene ID | 1192 |
| Uniprot ID | CLIC1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys241 |
Additional Info
| Post Translational Modifications | Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. |
| Protein Name | Chloride Intracellular Channel Protein 1Chloride Channel AbpGlutaredoxin-Like Oxidoreductase Clic1Glutathione-Dependent Dehydroascorbate Reductase Clic1Nuclear Chloride Ion Channel 27Ncc27Regulatory Nuclear Chloride Ion Channel ProteinHrncc |
| Database Links | |
| Cellular Localisation | NucleusNucleus MembraneSingle-Pass Membrane ProteinCytoplasmCell MembraneEndoplasmic ReticulumMostly In The Nucleus Including In The Nuclear MembraneSmall Amount In The Cytoplasm And The Plasma MembraneExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Protein Names | Chloride Intracellular Channel Protein 1 proteinChloride Channel Abp proteinGlutaredoxin-Like Oxidoreductase Clic1 proteinGlutathione-Dependent Dehydroascorbate Reductase Clic1 proteinNuclear Chloride Ion Channel 27 proteinNcc27 proteinRegulatory Nuclear Chloride Ion Channel Protein proteinHrncc proteinCLIC1 proteinG6 proteinNCC27 protein |
Information sourced from Uniprot.org