Human CLEC6A protein (Recombinant-Active) (N-His) (STJP012159)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CLEC6A-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to bind biotinylated alpha-D Mannose-PAA in a functional ELISA. |
Target Information
| Gene Symbol | CLEC6A |
| Gene ID | 93978 |
| Uniprot ID | CLC6A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr46-Leu209 |
Additional Info
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. |
| Protein Name | C-Type Lectin Domain Family 6 Member AC-Type Lectin Superfamily Member 10Dendritic Cell-Associated C-Type Lectin 2Dc-Associated C-Type Lectin 2Dectin-2 |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 6 Member A proteinC-Type Lectin Superfamily Member 10 proteinDendritic Cell-Associated C-Type Lectin 2 proteinDc-Associated C-Type Lectin 2 proteinDectin-2 proteinCLEC6A proteinCLECSF10 proteinDECTIN2 protein |
Information sourced from Uniprot.org