Human CLEC5A/MDL1 protein (Recombinant) (C-His) (STJP009265)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLEC5A/MDL1-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CLEC5A |
| Gene ID | 23601 |
| Uniprot ID | CLC5A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro28-Lys188 |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release. |
| Protein Name | C-Type Lectin Domain Family 5 Member AC-Type Lectin Superfamily Member 5Myeloid Dap12-Associating Lectin 1Mdl-1 |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 5 Member A proteinC-Type Lectin Superfamily Member 5 proteinMyeloid Dap12-Associating Lectin 1 proteinMdl-1 proteinCLEC5A proteinCLECSF5 proteinMDL1 protein |
Information sourced from Uniprot.org