Human CLEC2D protein (Recombinant) (N-hFc&Avi) {Biotin} (STJP020346)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human CLEC2D Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Arg60-Val191) of Human CLEC2D fused with a hFc and Avi tag at the N-terminal.
General Information
| Short Description | Recombinant-Human CLEC2D-N-hFc&Avi protein was developed in hek293 cells using the region Arg60-Val191. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CLEC2D |
| Gene ID | 29121 |
| Uniprot ID | CLC2D_HUMAN |
| Immunogen | Biotinylated Recombinant Human CLEC2D Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Arg60-Val191) of Human CLEC2D fused with a hFc and Avi tag at the N-terminal. |
| Immunogen Region | Arg60-Val191 |
Additional Info
| Tissue Specificity | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans. |
| Protein Name | C-Type Lectin Domain Family 2 Member DLectin-Like Nk Cell ReceptorLectin-Like Transcript 1Llt-1Osteoclast Inhibitory Lectin |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 2: Endoplasmic ReticulumIsoform 4: Endoplasmic Reticulum |
| Alternative Protein Names | C-Type Lectin Domain Family 2 Member D proteinLectin-Like Nk Cell Receptor proteinLectin-Like Transcript 1 proteinLlt-1 proteinOsteoclast Inhibitory Lectin proteinCLEC2D proteinCLAX proteinLLT1 proteinOCIL protein |
Information sourced from Uniprot.org