Human CLCN3 protein (Recombinant) (N-His) (STJP016218)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLCN3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CLCN3 |
| Gene ID | 1182 |
| Uniprot ID | CLCN3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu646-Asn818 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. |
| Protein Name | H(+/Cl(- Exchange Transporter 3Chloride Channel Protein 3Clc-3Chloride Transporter Clc-3 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneCell MembraneIsoform 1 Is Localized Mainly In Late EndosomesIsoform 2: Golgi Apparatus MembraneCell ProjectionRuffle MembraneIsoform 2 Is Mainly Enriched In The GolgiColocalizes With Nherf1/Ebp50 In Membrane Ruffles |
| Alternative Protein Names | H(+/Cl(- Exchange Transporter 3 proteinChloride Channel Protein 3 proteinClc-3 proteinChloride Transporter Clc-3 proteinCLCN3 protein |
Information sourced from Uniprot.org