Human CITED1 protein (Recombinant) (N-His) (STJP005921)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CITED1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CITED1 |
| Gene ID | 4435 |
| Uniprot ID | CITE1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Cys193 |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity. |
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling.stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. |
| Protein Name | Cbp/P300-Interacting Transactivator 1Melanocyte-Specific Protein 1 |
| Database Links | Reactome: R-HSA-8866907Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm By A Nuclear Export Signal And (Nes) In A Crm1-Dependent Manner |
| Alternative Protein Names | Cbp/P300-Interacting Transactivator 1 proteinMelanocyte-Specific Protein 1 proteinCITED1 proteinMSG1 protein |
Information sourced from Uniprot.org