Human CILK1 protein (Recombinant) (N-His) (STJP006219)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CILK1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CILK1 |
| Gene ID | 22858 |
| Uniprot ID | CILK1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gln277 |
Additional Info
| Post Translational Modifications | Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 increases kinase activity. |
| Function | Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity. |
| Protein Name | Serine/Threonine-Protein Kinase IckCiliogenesis Associated Kinase 1Intestinal Cell KinaseHickLaryngeal Cancer Kinase 2Lck2Mak-Related KinaseMrk |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosolCell ProjectionCiliumCytoskeletonCilium Basal BodyAlso Found At The Ciliary TipNuclear Localization Has Been Observed With A Gfp-Tagged Construct In Transfected Hela CellsIsoform 2: CytoplasmPredominant Cytoplasmic Localization Has Been Observed With A N-Terminally Gfp-Tagged Construct |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Ick proteinCiliogenesis Associated Kinase 1 proteinIntestinal Cell Kinase proteinHick proteinLaryngeal Cancer Kinase 2 proteinLck2 proteinMak-Related Kinase proteinMrk proteinCILK1 proteinICK proteinKIAA0936 protein |
Information sourced from Uniprot.org