Human CIAPIN1 protein (Recombinant) (His-Tag) (STJP018037)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CIAPIN1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIAPIN1 |
| Gene ID | 57019 |
| Uniprot ID | CPIN1_HUMAN |
| Accession Number | NP_064709 |
| Immunogen | Human |
| Immunogen Region | 1-312aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMADFGIS AGQFVAVVWD KSSPVEALKG LVDKLQALTG NEGRVSVENI KQLLQSAHKE SSFDIILSGL VPGSTTLHSA EILAEIARIL RPGGCLFLKE PVETAVDNNS KVKTASKLCS ALTLSGLVEV KELQREPLTP EEVQSVREHL GHESDNLLFV QITGKKPNFE VGSSRQLKLS ITKKSSPSVK PAVDPAAAKL WTLSANDM |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, liver and pancreas. |
| Function | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a 4Fe-4S cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. |
| Protein Name | AnamorsinCytokine-Induced Apoptosis Inhibitor 1Fe-S Cluster Assembly Protein Dre2 Homolog |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Intermembrane Space |
| Alternative Protein Names | Anamorsin proteinCytokine-Induced Apoptosis Inhibitor 1 proteinFe-S Cluster Assembly Protein Dre2 Homolog proteinCIAPIN1 proteinCUA001 proteinPRO0915 protein |
Information sourced from Uniprot.org