Human CIAO1 protein (Recombinant) (His-Tag) (STJP018113)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CIAO1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIAO1 |
| Gene ID | 9391 |
| Uniprot ID | CIAO1_HUMAN |
| Accession Number | NP_004795 |
| Immunogen | Human |
| Immunogen Region | 1-339aa |
| Immunogen Sequence |
Additional Info
| Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
| Protein Name | Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1Wd Repeat-Containing Protein 39 |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1 proteinWd Repeat-Containing Protein 39 proteinCIAO1 proteinCIA1 proteinWDR39 protein |
Information sourced from Uniprot.org