Human CHL1 protein (Recombinant) (N-His) (STJP003160)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CHL1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CHL1 |
| Gene ID | 10752 |
| Uniprot ID | NCHL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro35-Glu328 |
Additional Info
| Post Translational Modifications | Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. Cleaved by BACE1. N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). O-glycosylated. |
| Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. |
| Protein Name | Neural Cell Adhesion Molecule L1-Like ProteinClose Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein |
| Database Links | Reactome: R-HSA-447041 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Forms Produced By Cleavage/Shedding Also ExistProcessed Neural Cell Adhesion Molecule L1-Like Protein: SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Neural Cell Adhesion Molecule L1-Like Protein proteinClose Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein proteinCHL1 proteinCALL protein |
Information sourced from Uniprot.org