This CFLAR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.061ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
tissue homogenates, cell lysates or other biological fluids.
Additional Info
Tissue Specificity
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Post Translational Modifications
Proteolytically processed by CASP8 generating subunit p43 and p12.
Function
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Protein Name
Casp8 And Fadd-Like Apoptosis RegulatorCaspase HomologCashCaspase-Eight-Related ProteinCasperCaspase-Like Apoptosis Regulatory ProteinClarpCellular Flice-Like Inhibitory ProteinC-FlipFadd-Like Antiapoptotic Molecule 1Flame-1Inhibitor Of FliceI-FliceMach-Related Inducer Of ToxicityMritUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12
