Human CFI protein (Recombinant) (N-His) (STJP003709)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CFI-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CFI |
| Gene ID | 3426 |
| Uniprot ID | CFAI_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys19-Ile335 |
Additional Info
| Function | Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Protein Name | Complement Factor IC3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Protein Names | Complement Factor I proteinC3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain proteinCFI proteinIF protein |
Information sourced from Uniprot.org