Human CFH protein (Recombinant) (N-His) (STJP003856)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CFH-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CFH |
| Gene ID | 3075 |
| Uniprot ID | CFAH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu19-Pro346 |
Additional Info
| Post Translational Modifications | Sulfated on tyrosine residues. According to a report, Asn-217 is not glycosylated. Another study observed glycosylation at this position. |
| Function | Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. |
| Protein Name | Complement Factor HH Factor 1 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted(Microbial Infection) In The Mosquito MidgutLocalizes To PFalciparum (Nf54 Strain) Macrogamete And Young Zygote Cell Membranes |
| Alternative Protein Names | Complement Factor H proteinH Factor 1 proteinCFH proteinHF proteinHF1 proteinHF2 protein |
Information sourced from Uniprot.org