Human CERS2 protein (Recombinant) (N-His-SUMO) (STJP008958)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CERS2-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CERS2 |
| Gene ID | 29956 |
| Uniprot ID | CERS2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn81-Ser128 |
Additional Info
| Post Translational Modifications | Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. |
| Protein Name | Ceramide Synthase 2Cers2Lag1 Longevity Assurance Homolog 2Sp260Sphingosine N-Acyltransferase Cers2Tumor Metastasis-Suppressor Gene 1 ProteinVery-Long-Chain Ceramide Synthase Cers2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Ceramide Synthase 2 proteinCers2 proteinLag1 Longevity Assurance Homolog 2 proteinSp260 proteinSphingosine N-Acyltransferase Cers2 proteinTumor Metastasis-Suppressor Gene 1 Protein proteinVery-Long-Chain Ceramide Synthase Cers2 proteinCERS2 proteinLASS2 proteinTMSG1 protein |
Information sourced from Uniprot.org