Human CEP290 protein (Recombinant) (N-His) (STJP008353)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CEP290-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CEP290 |
| Gene ID | 80184 |
| Uniprot ID | CE290_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr1289-Arg1416 |
Additional Info
| Post Translational Modifications | Ubiquitinated. May undergo monoubiquitination.monoubiquitination is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, but does not cause its displacement from centriolar satellites. |
| Function | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells.may play a role in ciliary transport processes. Required for efficient recruitment of RAB8A to primary cilium. In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5. Activates ATF4-mediated transcription. |
| Protein Name | Centrosomal Protein Of 290 KdaCep290Bardet-Biedl Syndrome 14 ProteinCancer/Testis Antigen 87Ct87Nephrocystin-6Tumor Antigen Se2-2 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-6798695Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar SatelliteNucleusCell ProjectionCiliumCilium Basal BodyCentrioleCytoplasmic VesicleDisplaced From Centriolar Satellites In Response To Cellular StressSuch As Ultraviolet Light (Uv) Radiation Or Heat ShockFound In The Connecting Cilium Of Photoreceptor CellsBase Of Cilium In Kidney Intramedullary Collecting Duct CellsLocalizes At The Transition ZoneA Region Between The Basal Body And The Ciliary AxonemeLocalization At The Ciliary Transition Zone As Well As At Centriolar Satellites Is Bbsome-Dependent |
| Alternative Protein Names | Centrosomal Protein Of 290 Kda proteinCep290 proteinBardet-Biedl Syndrome 14 Protein proteinCancer/Testis Antigen 87 proteinCt87 proteinNephrocystin-6 proteinTumor Antigen Se2-2 proteinCEP290 proteinBBS14 proteinKIAA0373 proteinNPHP6 protein |
Information sourced from Uniprot.org