Human CEMIP protein (Recombinant) (N-His) (STJP005756)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CEMIP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CEMIP |
| Gene ID | 57214 |
| Uniprot ID | CEMIP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr31-Ala386 |
Additional Info
| Post Translational Modifications | N-glycosylated.glycosylation is not necessary for HA-binding. |
| Function | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. |
| Protein Name | Cell Migration-Inducing And Hyaluronan-Binding ProteinHyaluronan Binding Protein Involved In Hyaluronan Depolymerization |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumCell MembraneMembraneClathrin-Coated PitSecretedRetained In The Endoplasmic Reticulum (Er) In A Hspa5/Bip-Dependent MannerColocalized With Clathrin Heavy Chain/Cltc In Clathrin-Coated VesiclesStrongly Detected In The Cytoplasm Of Breast Carcinoma CellsWhereas Poorly Detected In Adjacent Normal Epithelial CellsStromal CellsOr Benign Breast TissuesLocalized In The Nucleus And Cytoplasm Of Colon Adenocarcinomas |
| Alternative Protein Names | Cell Migration-Inducing And Hyaluronan-Binding Protein proteinHyaluronan Binding Protein Involved In Hyaluronan Depolymerization proteinCEMIP proteinHYBID proteinKIAA1199 protein |
Information sourced from Uniprot.org