Human CELF2 protein (Recombinant) (N-His) (STJP007893)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CELF2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CELF2 |
| Gene ID | 10659 |
| Uniprot ID | CELF2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys41-Asp211 |
Additional Info
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA. |
| Protein Name | Cugbp Elav-Like Family Member 2Celf-2Bruno-Like Protein 3Cug Triplet Repeat Rna-Binding Protein 2Cug-Bp2Cug-Bp- And Etr-3-Like Factor 2Elav-Type Rna-Binding Protein 3Etr-3Neuroblastoma Apoptosis-Related Rna-Binding ProteinHnaporRna-Binding Protein Brunol-3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmAccumulates In The Cytoplasm After Ionizing RadiationColocalizes With Apobec1 And A1cfRna-Binding Activity Is Detected In Both Nuclear And Cytoplasmic Compartments |
| Alternative Protein Names | Cugbp Elav-Like Family Member 2 proteinCelf-2 proteinBruno-Like Protein 3 proteinCug Triplet Repeat Rna-Binding Protein 2 proteinCug-Bp2 proteinCug-Bp- And Etr-3-Like Factor 2 proteinElav-Type Rna-Binding Protein 3 proteinEtr-3 proteinNeuroblastoma Apoptosis-Related Rna-Binding Protein proteinHnapor proteinRna-Binding Protein Brunol-3 proteinCELF2 proteinBRUNOL3 proteinCUGBP2 proteinETR3 proteinNAPOR protein |
Information sourced from Uniprot.org