Human CEACAM5/CEA/CD66e protein (Recombinant) (C-His) (STJP019966)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CEACAM5/CEA/CD66e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Ala685) of Human CEACAM5/CD66e (Accession #P06731-1) fused with a C-His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CEACAM5/CEA/CD66e-C-His protein was developed in hek293 cells using the region Lys35-Ala685. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CEACAM5 |
| Gene ID | 1048 |
| Uniprot ID | CEAM5_HUMAN |
| Immunogen | Recombinant Human CEACAM5/CEA/CD66e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Ala685) of Human CEACAM5/CD66e (Accession #P06731-1) fused with a C-His tag at the C-terminus. |
| Immunogen Region | Lys35-Ala685 |
| Immunogen Sequence | KLTIESTPFNVAEGKEVLLL VHNLPQHLFGYSWYKGERVD GNRQIIGYVIGTQQATPGPA YSGREIIYPNASLLIQNIIQ NDTGFYTLHVIKSDLVNEEA TGQFRVYPELPKPSISSNNS KPVEDKDAVAFTCEPETQDA TYLWWVNNQSLPVSPRLQLS NGNRTLTLFNVTRNDTASYK CETQNPVSARRSDSVILNVL YGPDAPTISPLNTSYRSGEN LNLSCHAASNPPAQYSWFV |
Additional Info
| Tissue Specificity | Expressed in columnar epithelial and goblet cells of the colon (at protein level). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. |
| Post Translational Modifications | Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression.induces resistance to anoikis of colorectal carcinoma cells. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. |
| Protein Name | Cell Adhesion Molecule Ceacam5Carcinoembryonic AntigenCeaCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5Cea Cell Adhesion Molecule 5Meconium Antigen 100Cd Antigen Cd66e |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneCell SurfaceLocalized To The Apical Glycocalyx Surface |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam5 proteinCarcinoembryonic Antigen proteinCea proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5 proteinCea Cell Adhesion Molecule 5 proteinMeconium Antigen 100 proteinCd Antigen Cd66e proteinCEACAM5 proteinCEA protein |
Information sourced from Uniprot.org