Human CDK2AP2 protein (Recombinant) (N-His-KSI) (STJP016193)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDK2AP2-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CDK2AP2 |
| Gene ID | 10263 |
| Uniprot ID | CDKA2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn49-Thr126 |
Additional Info
| Post Translational Modifications | Phosphorylated by MAPK1 and CDK2. |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation.represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. |
| Protein Name | Cyclin-Dependent Kinase 2-Associated Protein 2Cdk2-Associated Protein 2Doc-1-Related ProteinDoc-1r |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusAccumulates In Immature Oocytes In The NucleusDuring The First Meiotic DivisionAccumulates In The Cytoplasm And Localizes In Dots In The Vicinity Of The Chromosomes In A Region Enriched In Microtubules |
| Alternative Protein Names | Cyclin-Dependent Kinase 2-Associated Protein 2 proteinCdk2-Associated Protein 2 proteinDoc-1-Related Protein proteinDoc-1r proteinCDK2AP2 proteinDOC1R protein |
Information sourced from Uniprot.org