Human CDK2AP2 protein (Recombinant) (His-Tag) (STJP017975)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CDK2AP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDK2AP2 |
| Gene ID | 10263 |
| Uniprot ID | CDKA2_HUMAN |
| Accession Number | NP_005842 |
| Immunogen | Human |
| Immunogen Region | 1-126aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated by MAPK1 and CDK2. |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation.represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. |
| Protein Name | Cyclin-Dependent Kinase 2-Associated Protein 2Cdk2-Associated Protein 2Doc-1-Related ProteinDoc-1r |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusAccumulates In Immature Oocytes In The NucleusDuring The First Meiotic DivisionAccumulates In The Cytoplasm And Localizes In Dots In The Vicinity Of The Chromosomes In A Region Enriched In Microtubules |
| Alternative Protein Names | Cyclin-Dependent Kinase 2-Associated Protein 2 proteinCdk2-Associated Protein 2 proteinDoc-1-Related Protein proteinDoc-1r proteinCDK2AP2 proteinDOC1R protein |
Information sourced from Uniprot.org