Human CDK14 protein (Recombinant) (N-His) (STJP003414)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDK14-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDK14 |
| Gene ID | 5218 |
| Uniprot ID | CDK14_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Tyr135-Phe419 |
Additional Info
| Function | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. |
| Protein Name | Cyclin-Dependent Kinase 14Cell Division Protein Kinase 14Serine/Threonine-Protein Kinase Pftaire-1Hpftaire1 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmNucleusRecruited To The Cell Membrane By Ccny |
| Alternative Protein Names | Cyclin-Dependent Kinase 14 proteinCell Division Protein Kinase 14 proteinSerine/Threonine-Protein Kinase Pftaire-1 proteinHpftaire1 proteinCDK14 proteinKIAA0834 proteinPFTK1 protein |
Information sourced from Uniprot.org