Human CDK12 protein (Recombinant) (N-His) (STJP008069)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDK12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDK12 |
| Gene ID | 51755 |
| Uniprot ID | CDK12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser717-Gly1054 |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-893 increases kinase activity. |
| Function | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
| Protein Name | Cyclin-Dependent Kinase 12Cdc2-Related Kinase - Arginine/Serine-RichCrkrsCell Division Cycle 2-Related Protein Kinase 7Cdc2-Related Protein Kinase 7Cell Division Protein Kinase 12Hcdk12 |
| Database Links | Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusNucleus SpeckleColocalized With Nuclear Speckles Throughout Interphase |
| Alternative Protein Names | Cyclin-Dependent Kinase 12 proteinCdc2-Related Kinase - Arginine/Serine-Rich proteinCrkrs proteinCell Division Cycle 2-Related Protein Kinase 7 proteinCdc2-Related Protein Kinase 7 proteinCell Division Protein Kinase 12 proteinHcdk12 proteinCDK12 proteinCRK7 proteinCRKRS proteinKIAA0904 protein |
Information sourced from Uniprot.org