Human CDK11B protein (Recombinant) (N-His) (STJP015299)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDK11B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CDK11B |
| Gene ID | 984 |
| Uniprot ID | CD11B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser434-Thr726 |
Additional Info
| Post Translational Modifications | During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11bCell Division Cycle 2-Like Protein Kinase 1Clk-1Cell Division Protein Kinase 11bGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l1P58 Clk-1 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Cyclin-Dependent Kinase 11b proteinCell Division Cycle 2-Like Protein Kinase 1 proteinClk-1 proteinCell Division Protein Kinase 11b proteinGalactosyltransferase-Associated Protein Kinase P58/Gta proteinPitslre Serine/Threonine-Protein Kinase Cdc2l1 proteinP58 Clk-1 proteinCDK11B proteinCDC2L1 proteinCDK11 proteinPITSLREA proteinPK58 protein |
Information sourced from Uniprot.org