| Short Description : | Recombinant-Human CDH6/K-Cadherin-C-His protein was developed in hek293 cells using the region Thr 19-Ala 615. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human CDH6 at 1 Mu g/mL (100 Mu L/well) can bind CDH6 Mouse mAb with a linear range of 0.05-6.31 ng/mL. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CDH6 |
| Gene ID: | 1004 |
| Uniprot ID: | CADH6_HUMAN |
| Immunogen: | Recombinant Human CDH6/K-Cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr 19-Ala 615 ) of human K-Cadherin (Accession #NP_004923.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Thr 19-Ala 615 |
| Immunogen Sequence: | TLSTPLSKRTSGFPAKKRAL ELSGNSKNELNRSKRSWMWN QFFLLEEYTGSDYQYVGKLH SDQDRGDGSLKYILSGDGAG DLFIINENTGDIQATKRLDR EEKPVYILRAQAINRRTGRP VEPESEFIIKIHDINDNEPI FTKEVYTATVPEMSDVGTFV VQVTATDADDPTYGNSAKVV YSILQGQPYFSVESETGIIK TALLNMDRENREQYQVVIQA KDMGGQMGGLSGTTTVNIT |
| Tissue Specificity | Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Protein Name | Cadherin-6Kidney CadherinK-Cadherin |
| Database Links | Reactome: R-HSA-418990 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cadherin-6 proteinKidney Cadherin proteinK-Cadherin proteinCDH6 protein |
Information sourced from Uniprot.org
