Human CDH17/LI-cadherin protein (Recombinant) (C-His) (STJP000884)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CDH17/LI-cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln23-Met787) of human Cadherin-17/LI-cadherin/CDH17 (Accession #NP_001138135.1) fused with a 6×His tag at the C
General Information
| Short Description | Recombinant-Human CDH17/LI-cadherin-C-His protein was developed in hek293 cells using the region Gln23-Met787. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 1 Mu g/mL (100 Mu L/well) can bind anti Human CDH17 antibody with a linear range of 0.01-20ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CDH17 |
| Gene ID | 1015 |
| Uniprot ID | CAD17_HUMAN |
| Immunogen | Recombinant Human CDH17/LI-cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln23-Met787) of human Cadherin-17/LI-cadherin/CDH17 (Accession #NP_001138135.1) fused with a 6×His tag at the C |
| Immunogen Region | Gln23-Met787 |
| Immunogen Sequence | QEGKFSGPLKPMTFSIYEGQ EPSQIIFQFKANPPAVTFEL TGETDNIFVIEREGLLYYNR ALDRETRSTHNLQVAALDAN GIIVEGPVPITIKVKDINDN RPTFLQSKYEGSVRQNSRPG KPFLYVNATDLDDPATPNGQ LYYQIVIQLPMINNVMYFQI NNKTGAISLTREGSQELNPA KNPSYNLVISVKDMGGQSEN SFSDTTSVDIIVTENIWKAP KPVEMVENSTDPHPIKITQ |
Additional Info
| Tissue Specificity | Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. |
| Protein Name | Cadherin-17Intestinal Peptide-Associated Transporter Hpt-1Liver-Intestine CadherinLi-Cadherin |
| Database Links | Reactome: R-HSA-418990 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cadherin-17 proteinIntestinal Peptide-Associated Transporter Hpt-1 proteinLiver-Intestine Cadherin proteinLi-Cadherin proteinCDH17 protein |
Information sourced from Uniprot.org