Human CDCA2 protein (Recombinant) (N-GST & C-His) (STJP008886)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDCA2-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDCA2 |
| Gene ID | 157313 |
| Uniprot ID | CDCA2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala383-Glu441 |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1. May regulate its subcellular location. |
| Function | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. |
| Protein Name | Cell Division Cycle-Associated Protein 2Recruits Pp1 Onto Mitotic Chromatin At Anaphase ProteinRepo-Man |
| Database Links | |
| Cellular Localisation | NucleusExcluded From The NucleolusPresent In Nucleoplasm Throughout The G1S And G2 Stages Of The Cell CycleDuring M PhaseIt Becomes Diffuse Throughout The Cell As The Nuclear Membrane Breaks DownAnd Faintly Accumulates Later On Metaphase ChromatinAs The Cell Progresses To AnaphaseIt Accumulates On Chromatin |
| Alternative Protein Names | Cell Division Cycle-Associated Protein 2 proteinRecruits Pp1 Onto Mitotic Chromatin At Anaphase Protein proteinRepo-Man proteinCDCA2 protein |
Information sourced from Uniprot.org