Human CDC5L protein (Recombinant) (N-His) (STJP011348)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CDC5L-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDC5L |
| Gene ID | 988 |
| Uniprot ID | CDC5L_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser591-Glu851 |
Additional Info
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. |
| Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Protein Name | Cell Division Cycle 5-Like ProteinCdc5-Like ProteinPombe Cdc5-Related Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmMay Shuttle Between Cytoplasm And Nucleus |
| Alternative Protein Names | Cell Division Cycle 5-Like Protein proteinCdc5-Like Protein proteinPombe Cdc5-Related Protein proteinCDC5L proteinKIAA0432 proteinPCDC5RP protein |
Information sourced from Uniprot.org