Human CD93/C1q R1 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001565)
SPECIFICATIONS
HostHEK293
ConjugationBiotin
ImmunogenDNA sequence encoding Human CD93/C1q R1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
General Information
| Short Description | Recombinant-Human CD93/C1q R1-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
Target Information
| Gene Symbol | CD93 |
| Gene ID | 22918 |
| Uniprot ID | C1QR1_HUMAN |
| Immunogen | DNA sequence encoding Human CD93/C1q R1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region | Thr22-Lys580 |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration. |
| Function | Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function. |
| Protein Name | Complement Component C1q ReceptorC1q/Mbl/Spa ReceptorC1qrC1qr(PC1qrpCdw93Complement Component 1 Q Subcomponent Receptor 1Matrix-Remodeling-Associated Protein 4Cd Antigen Cd93 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Complement Component C1q Receptor proteinC1q/Mbl/Spa Receptor proteinC1qr proteinC1qr(P proteinC1qrp proteinCdw93 proteinComplement Component 1 Q Subcomponent Receptor 1 proteinMatrix-Remodeling-Associated Protein 4 proteinCd Antigen Cd93 proteinCD93 proteinC1QR1 proteinMXRA4 protein |
Information sourced from Uniprot.org