Human CD85j/LILRB1/ILT2 protein (Recombinant-Active) (C-His) (STJP012207)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD85j/LILRB1/ILT2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | When recombinant human CD85j/LILRB1/ILT2 is coated at 2 ยตg/mL, recombinant human ANGPTL7 binds with a typical ED50 of 0.02-0.2 Mu g/mL. |
Target Information
| Gene Symbol | LILRB1 |
| Gene ID | 10859 |
| Uniprot ID | LIRB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly24-His458 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1Lir-1Leukocyte Immunoglobulin-Like Receptor 1Cd85 Antigen-Like Family Member JImmunoglobulin-Like Transcript 2Ilt-2Monocyte/Macrophage Immunoglobulin-Like Receptor 7Mir-7Cd Antigen Cd85j |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 5: Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 proteinLir-1 proteinLeukocyte Immunoglobulin-Like Receptor 1 proteinCd85 Antigen-Like Family Member J proteinImmunoglobulin-Like Transcript 2 proteinIlt-2 proteinMonocyte/Macrophage Immunoglobulin-Like Receptor 7 proteinMir-7 proteinCd Antigen Cd85j proteinLILRB1 proteinILT2 proteinLIR1 proteinMIR7 protein |
Information sourced from Uniprot.org