Human CD85d/LILRB2/ILT4 protein (Recombinant-Active) (C-His) (STJP012202)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD85d/LILRB2/ILT4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human CD85d/LILRB2/ILT4 is coated at 2 µg/mL, recombinant human ANGPTL7 binds with a typical ED50 of 25-150 ng/mL. |
Target Information
| Gene Symbol | LILRB2 |
| Gene ID | 10288 |
| Uniprot ID | LIRB2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln22-Leu458 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2Lir-2Leukocyte Immunoglobulin-Like Receptor 2Cd85 Antigen-Like Family Member DImmunoglobulin-Like Transcript 4Ilt-4Monocyte/Macrophage Immunoglobulin-Like Receptor 10Mir-10Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 proteinLir-2 proteinLeukocyte Immunoglobulin-Like Receptor 2 proteinCd85 Antigen-Like Family Member D proteinImmunoglobulin-Like Transcript 4 proteinIlt-4 proteinMonocyte/Macrophage Immunoglobulin-Like Receptor 10 proteinMir-10 proteinCd Antigen Cd85d proteinLILRB2 proteinILT4 proteinLIR2 proteinMIR10 protein |
Information sourced from Uniprot.org