Human CD70/TNFSF7/CD27 Ligand protein (Recombinant) (N-6His) (STJP001900)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CD70/TNFSF7/CD27 Ligand Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln39-Pro193) of human CD70/TNFSF7/CD27 Ligand (Accession #NP_001243.1) fused with and a 6×His tag at the
General Information
| Short Description | Recombinant-Human CD70/TNFSF7/CD27 Ligand-N-6His protein was developed in hek293 cells using the region Gln39-Pro193. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF7 at 2 Mu g/mL (100 Mu L/well) can bind Human TNFRSF7 with a linear range of 0.2-82 ng/mL. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | CD70 |
| Gene ID | 970 |
| Uniprot ID | CD70_HUMAN |
| Immunogen | Recombinant Human CD70/TNFSF7/CD27 Ligand Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln39-Pro193) of human CD70/TNFSF7/CD27 Ligand (Accession #NP_001243.1) fused with and a 6×His tag at the |
| Immunogen Region | Gln39-Pro193 |
| Immunogen Sequence | QRFAQAQQQLPLESLGWDVA ELQLNHTGPQQDPRLYWQGG PALGRSFLHGPELDKGQLRI HRDGIYMVHIQVTLAICSST TASRHHPTTLAVGICSPASR SISLLRLSFHQGCTIASQRL TPLARGDTLCTNLTGTLLPS RNTDETFFGVQWVRP |
Additional Info
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 AntigenCd27 LigandCd27-LTumor Necrosis Factor Ligand Superfamily Member 7Cd Antigen Cd70 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Cd70 Antigen proteinCd27 Ligand proteinCd27-L proteinTumor Necrosis Factor Ligand Superfamily Member 7 proteinCd Antigen Cd70 proteinCD70 proteinCD27L proteinCD27LG proteinTNFSF7 protein |
Information sourced from Uniprot.org