Human CD66d/CEACAM3 protein (Recombinant) (His-Tag) (STJP018989)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CD66d/CEACAM3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CEACAM3 |
| Gene ID | 1084 |
| Uniprot ID | CEAM3_HUMAN |
| Accession Number | NP_001264092 |
| Immunogen | Human |
| Immunogen Region | 35-155aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSKLTIESM PLSVAEGKEV LLLVHNLPQH LFGYSWYKGE RVDGNSLIVG YVIGTQQATP GAAYSGRETI YTNASLLIQN VTQNDIGFYT LQVIKSDLVN EEATGQFHVY QENAPGLPVG AVAG |
Additional Info
| Tissue Specificity | CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. |
| Post Translational Modifications | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. |
| Function | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. |
| Protein Name | Cell Adhesion Molecule Ceacam3Carcinoembryonic Antigen Cgm1Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3Cea Cell Adhesion Molecule 3Cd Antigen Cd66d |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam3 proteinCarcinoembryonic Antigen Cgm1 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 3 proteinCea Cell Adhesion Molecule 3 proteinCd Antigen Cd66d proteinCEACAM3 proteinCD66D proteinCGM1 protein |
Information sourced from Uniprot.org