Human CD66d/CEACAM3 protein (Recombinant-Active) (C-His) (STJP011985)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD66d/CEACAM3-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | When recombinant human CD66d/CEACAM3 is Immobilised at 2 µg/mL (100 µL/well) , the concentration of recombinant human CEACAM-7 that produces 50% of the optimal binding response is 0.6-3.6 Mu g/mL. |
Target Information
| Gene Symbol | CEACAM3 |
| Gene ID | 1084 |
| Uniprot ID | CEAM3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys35-Gly155 |
Additional Info
| Post Translational Modifications | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. |
| Function | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. |
| Protein Name | Cell Adhesion Molecule Ceacam3Carcinoembryonic Antigen Cgm1Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3Cea Cell Adhesion Molecule 3Cd Antigen Cd66d |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam3 proteinCarcinoembryonic Antigen Cgm1 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 3 proteinCea Cell Adhesion Molecule 3 proteinCd Antigen Cd66d proteinCEACAM3 proteinCD66D proteinCGM1 protein |
Information sourced from Uniprot.org