Human CD66c/CEACAM6 protein (Recombinant-Active) (C-His) (STJP011986)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD66c/CEACAM6-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by the ability of the Immobilised protein to support the adhesion of calcium ionophore treated human neutrophils. When 2 x 10^5 cells/well are added to CD66c/CEACAM6 coated plates (10 µg/mL, 100 µL/well) , 35 ‑ 60% of the cells will adhere a |
Target Information
| Gene Symbol | CEACAM6 |
| Gene ID | 4680 |
| Uniprot ID | CEAM6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys35-Gly320 |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role in cell migration and cell adhesion to endothelial cells. |
| Protein Name | Cell Adhesion Molecule Ceacam6Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6Cea Cell Adhesion Molecule 6Non-Specific Crossreacting AntigenNormal Cross-Reacting AntigenCd Antigen Cd66c |
| Database Links | Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneCell SurfaceLocalized To The Apical Glycocalyx Surface |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam6 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 6 proteinCea Cell Adhesion Molecule 6 proteinNon-Specific Crossreacting Antigen proteinNormal Cross-Reacting Antigen proteinCd Antigen Cd66c proteinCEACAM6 proteinNCA protein |
Information sourced from Uniprot.org