Human CD55 (CD55) Antibody Pair (STJAP00857)
General Information
| Short Description | This CD55 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R02-8L-9/R06-4O-4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CD55 |
| Gene ID | 1604 |
| Uniprot ID | DAF_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. |
| Post Translational Modifications | The Ser/Thr-rich domain is heavily O-glycosylated. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. |
| Protein Name | Complement Decay-Accelerating FactorCd Antigen Cd55 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneLipid-AnchorGpi-AnchorIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Cell MembraneIsoform 7: Cell Membrane |
| Alternative Antibody Pair Names | Complement Decay-Accelerating Factor antibody pairCd Antigen Cd55 antibody pairCD55 antibody pairCR antibody pairDAF antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human CD55 (CD55) Antibody Pair (STJAP00857)
This antibody pair detects human CD55 (UniProt P08174) and has confirmed reactivity in human samples only. It is intended for in vitro research use only.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated and affinity purified, formulated in 0.01M PBS at pH 7.2. Clone IDs are R02-8L-9 and R06-4O-4 for the two components of the pair.
This antibody pair is validated for use in ELISA. No other assay formats are listed as validated for this product.
Optimal working concentrations are to be determined by the end user and are not predefined in the product specifications. Titration experiments are recommended to establish appropriate dilutions for each specific experimental setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C, and avoid repeated freeze/thaw cycles.
Both antibodies were raised in rabbit against a recombinant protein immunogen and purified by affinity purification. Both are monoclonal antibodies supplied as unconjugated IgG.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.