Human CD49f/ITGA6 protein (Recombinant) (N-His) (STJP007271)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD49f/ITGA6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ITGA6 |
| Gene ID | 3655 |
| Uniprot ID | ITA6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala23-Gln462 |
Additional Info
| Post Translational Modifications | Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p). Production of alpha6p enhances prostate cancer cell invasion and migration. Palmitoylation by DHHC3 enhances stability and cell surface expression. |
| Function | Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
| Protein Name | Integrin Alpha-6Cd49 Antigen-Like Family Member FVla-6Cd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6Alpha6p |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-446107Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-Anchor |
| Alternative Protein Names | Integrin Alpha-6 proteinCd49 Antigen-Like Family Member F proteinVla-6 proteinCd Antigen Cd49f Cleaved Into - Integrin Alpha-6 Heavy Chain - Integrin Alpha-6 Light Chain - Processed Integrin Alpha-6 proteinAlpha6p proteinITGA6 protein |
Information sourced from Uniprot.org