Human CD48 protein (Recombinant-Active) (C-His) (STJP011834)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD48-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Immobilised recombinant human CD48 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human CD244 with a linear range of 0.2-1 Mu g/mL. |
Target Information
| Gene Symbol | CD48 |
| Gene ID | 962 |
| Uniprot ID | CD48_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln27-Ser220 |
Additional Info
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinB-Lymphocyte Activation Marker Blast-1 proteinBcm1 Surface Antigen proteinLeukocyte Antigen Mem-102 proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinTct.1 proteinCd Antigen Cd48 proteinCD48 proteinBCM1 proteinBLAST1 protein |
Information sourced from Uniprot.org